WP02 - Isolation of clinical grade umbilical cord blood regulatory T cells to treat Graft versus Host Disease

Objectives of the workpackage

  • Isolation of clinical grade primary regulatory T cells from umbilical cord blood
  • Development of a primary regulatory T cell product as an off-the-shelf therapeutic for the control of Graft versus Host Disease

 

Workpackage description

The main aim of this workpackage is to develop a primary regulatory T cell product as a clinical therapy for GVHD; to be a tool alongside the other clinical products, developed in the other work packages, to combat the main complications in haematopoietic stem cell transplantation.

The different tasks of this workpackage are:

  • To establish a Streptamer-based isolation method for high purity, UCB p-Treg
  • To perform a functional characterisation of the p-Tregs in order to develop a quality control procedure for product release
  • To monitor the transferred pT-regs in patients to correlate cell numbers and function with clinical outcome